Gout | NEJM
Recognizing Gout Symptoms
Gout attacks typically come on suddenly, often at night. Symptoms include:
- Intense Joint Pain: The pain is often excruciating and can make it difficult to walk or even tolerate light touch.
- Inflammation: The affected joint becomes swollen, red, and warm.
- Limited Range of Motion: The pain and inflammation can restrict your ability to move the joint.
- Tophi: In chronic gout, uric acid crystals can form lumps under the skin called tophi. These can appear on the fingers, toes, elbows, or ears.
Managing Gout: Treatment and Prevention
Gout management involves two key strategies: treating acute flares and preventing future attacks.
Treating Acute Gout Flares
Medications: Several medications can relieve pain and inflammation during a gout attack, including:
- Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Over-the-counter or prescription NSAIDs can reduce pain and inflammation.
- Colchicine: This medication can effectively relieve gout pain, especially when taken within the first 24 hours of an attack.
- Corticosteroids: These powerful anti-inflammatory drugs can be taken orally or injected into the affected joint.
Rest and Ice: Resting the affected joint and applying ice packs can help reduce pain and swelling.
Hydration: Drinking plenty of water helps flush uric acid from your system.
Preventing Future Gout Attacks
The goal of preventive treatment is to lower uric acid levels and keep them within a target range. This typically involves:
Medications:
- Urate-Lowering Therapy (ULT): Medications like allopurinol and febuxostat reduce the production of uric acid. Probenecid helps your kidneys remove uric acid from your body. ULT is typically started after a gout flare has subsided.
- Pegloticase: This medication is used for severe gout that doesn't respond to other treatments. It breaks down uric acid in the body.
Lifestyle Modifications: Making changes to your diet and lifestyle can also help prevent gout attacks:
- Limit Purine-Rich Foods: Reduce your intake of red meat, organ meats, seafood, and sugary drinks.
- Moderate Alcohol Consumption: Limit alcohol intake, especially beer and hard liquor.
- Maintain a Healthy Weight: Losing weight can help lower uric acid levels.
- Stay Hydrated: Drink plenty of water to help flush uric acid from your system.
- Manage Other Medical Conditions: Effectively managing conditions like high blood pressure, diabetes, and kidney disease can help reduce your risk of gout.
