Gout | NEJM

Recognizing Gout Symptoms

Gout attacks typically come on suddenly, often at night. Symptoms include:

  • Intense Joint Pain: The pain is often excruciating and can make it difficult to walk or even tolerate light touch.
  • Inflammation: The affected joint becomes swollen, red, and warm.
  • Limited Range of Motion: The pain and inflammation can restrict your ability to move the joint.
  • Tophi: In chronic gout, uric acid crystals can form lumps under the skin called tophi. These can appear on the fingers, toes, elbows, or ears.

Managing Gout: Treatment and Prevention

Gout management involves two key strategies: treating acute flares and preventing future attacks.

Treating Acute Gout Flares

  • Medications: Several medications can relieve pain and inflammation during a gout attack, including:

    • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Over-the-counter or prescription NSAIDs can reduce pain and inflammation.
    • Colchicine: This medication can effectively relieve gout pain, especially when taken within the first 24 hours of an attack.
    • Corticosteroids: These powerful anti-inflammatory drugs can be taken orally or injected into the affected joint.
  • Rest and Ice: Resting the affected joint and applying ice packs can help reduce pain and swelling.

  • Hydration: Drinking plenty of water helps flush uric acid from your system.

Preventing Future Gout Attacks

The goal of preventive treatment is to lower uric acid levels and keep them within a target range. This typically involves:

  • Medications:

    • Urate-Lowering Therapy (ULT): Medications like allopurinol and febuxostat reduce the production of uric acid. Probenecid helps your kidneys remove uric acid from your body. ULT is typically started after a gout flare has subsided.
    • Pegloticase: This medication is used for severe gout that doesn't respond to other treatments. It breaks down uric acid in the body.
  • Lifestyle Modifications: Making changes to your diet and lifestyle can also help prevent gout attacks:

    • Limit Purine-Rich Foods: Reduce your intake of red meat, organ meats, seafood, and sugary drinks.
    • Moderate Alcohol Consumption: Limit alcohol intake, especially beer and hard liquor.
    • Maintain a Healthy Weight: Losing weight can help lower uric acid levels.
    • Stay Hydrated: Drink plenty of water to help flush uric acid from your system.
    • Manage Other Medical Conditions: Effectively managing conditions like high blood pressure, diabetes, and kidney disease can help reduce your risk of gout.

    Image of gout in toe joint